Publications at the Gu Lab
2025
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Nardone C†, Gao J†, Seo H, Mintseris J, Ort L, Yip MC, Negasi M, Besschetnova AK, Kamitak Ni, Gygi SP, Dhe-Paganon S, Munshi N, Fulciniti M, Greenberg ME, Shao S*, Elledge SJ*, Gu X* Molecular Cell. 2025 July; 85(13), 2597-2609.e11. https://doi.org/10.1016/j.molcel.2025.05.030 | ||
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Determination of Nutrient Ligand-Sensor Binding Affinity
Gu X†. (2025). In: Russell, F.M., Hardie, D.G. (eds) Nutrient Sensing in Eukaryotes. Methods in Molecular Biology (Clifton, N.J.), 2882, 163–178. https://doi.org/10.1007/978-1-0716-4284-9_8 | ||
2024
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Structure of the TXNL1-bound proteasome.
Gao J†, Nardone C†, Yip MCJ†, Chino H, Gu X, Mirman Z, Rale MJ, Paulo JA, Elledge SJ*, Shao S*. bioRxiv 2024.11.08.622741; doi: https://doi.org/10.1101/2024.11.08.622741 | ||
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Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway.
Valenstein ML†*, Lalgudi PV†, Gu X†, Kedir JF, Taylor MS, Chivukula RR, Sabatini DM*. Proc Natl Acad Sci USA. 2024 Aug 20; 121(35): e2322755121. PMID: 39163330. | ||
2023
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The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.
Gu X†, Nardone C†, Kamitaki N, Mao A, Elledge SJ*, Greenberg ME*. Science. 2023 Aug 25;381(6660):eadh5021. PMID: 37616343. Preview. Schilling CM, Weber-Ban E*. Catching proteins for degradation. Science. 2023 Aug 25;381(6660):834-835. PMID: 37616357. | ||
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The Rag GTPases-mTORC1-TFE3 axis in kidney cancer and neurodevelopment: a mini review.
Nardone C, Gu X, Elledge SJ*. J Neurol Neuromedicine. 2023 Jan doi: 10.29245/2572.942X/2023/1.1287. | ||
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A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.
Nardone C, Palanski BA, Scott DC, Timms RT, Barber KW, Gu X, Mao A, Leng Y, Watson EV, Schulman BA, Cole PA, Elledge SJ*. Mol Cell. 2023 Jan 5;83(1):57-73 e9. PMID: 36608670. | ||
2022
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Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.
Gu X†*, Jouandin P†*, Lalgudi PV, Binari R, Valenstein ML, Reid MA, Allen AE, Kamitaki N, Locasale JW, Perrimon N*, Sabatini DM. Nature. 2022 Aug;608(7921):209-216. PMID: 35859173. | ||
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Structure of the nutrient-sensing hub GATOR2.
Valenstein ML†*, Rogala KB†*, Lalgudi PV, Brignole EJ, Gu X, Saxton RA, Chantranupong L, Kolibius J, Quast JP, Sabatini DM. Nature. 2022 Jul;607(7919):610-616. PMID: 35831510. | ||
2021
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Nanoscale Insights into the Mechanisms of Cellular Growth and Proliferation.
Rogala KB, Gu X, Kedir JF, Abu-Remaileh M, Bianchi LF, Bottino AMS, Dueholm R, Niehaus A, Overwijn D, Fils AP, Zhou SX, Leary D, Laqtom NN, Brignole EJ, Sabatini DM*. Biological, Medical Devices, and Systems, Microsystems Annual Research Report 2021. | ||
2019
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Structural basis for the docking of mTORC1 on the lysosomal surface.
Rogala KB, Gu X, Kedir JF, Abu-Remaileh M, Bianchi LF, Bottino AMS, Dueholm R, Niehaus A, Overwijn D, Fils AP, Zhou SX, Leary D, Laqtom NN, Brignole EJ, Sabatini DM*. Science. 2019 Oct 25;366(6464):468-475. PMID: 31601708. | ||
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Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.
Shen K, Valenstein ML, Gu X, Sabatini DM*. J Biol Chem. 2019 Feb 22;294(8):2970-2975. PMID: 30651352. | ||
2017
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SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.
Gu X†, Orozco JM†, Saxton RA, Condon KJ, Liu GY, Krawczyk PA, Scaria SM, Harper JW, Gygi SP, Sabatini DM*. Science. 2017 Nov 10;358(6364):813-818. PMID: 29123071. | ||
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A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.
Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz OH, Xue W, Katajisto P, Bhutkar A, Jacks T*. Nature. 2017 May 18;545(7654):355-359. PMID: 28489818. | ||
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KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Wolfson RL†, Chantranupong L†, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM*. Nature. 2017 Mar 16;543(7645):438-442. PMID: 28199306. | ||
2015
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The lamin-A/C-LAP2alpha-BAF1 protein complex regulates mitotic spindle assembly and positioning.
Qi R, Xu N, Wang G, Ren H, Li S, Lei J, Lin Q, Wang L, Gu X, Zhang H, Jiang Q, Zhang C*. J Cell Sci. 2015 Aug 1;128(15):2830-41. PMID: 26092935. | ||